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Targeted Allele Detail
Symbol: Hsf1tm1Miv
Name: heat shock factor 1; targeted mutation 1, Nahid F Mivechi
MGI ID: MGI:3033933
Synonyms: hsf1-
Gene: Hsf1  Location: Chr15:76477445-76500972 bp, + strand  Genetic Position: Chr15, 35.95 cM
Testes are smaller in Hsf2tm1Miv/Hsf2tm1Miv and Hsf1tm1Miv/Hsf1tm1Miv Hsf2tm1Miv/Hsf2tm1Miv mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:88534
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 55 bp segment of exon 2 was replaced with a cassette containing IRES, lacZ, and a floxed PGK-neomycin resistance gene. The DNA binding domain was disrupted and a frame shift was created in the process. A shorter mRNA transcript in which exon 1 is spliced directly to exon 3 was detected by Northern blot analysis. Immunoblot analysis indicated the absence of any protein product. Beta-galactosidase expression was not detected. (J:88534)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsf1 Mutation:  7 strains or lines available
Original:  J:88534 Zhang Y, et al., Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue-specific regulation for stress-inducible Hsp molecular chaperones. J Cell Biochem. 2002;86(2):376-93
All:  5 reference(s)

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MGI 6.03
The Jackson Laboratory