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Targeted Allele Detail
Symbol: Vsx1tm2Mci
Name: visual system homeobox 1; targeted mutation 2, Roderick R McInnes
MGI ID: MGI:3033931
Synonyms: Vsx1:taulLacZ, VsxtauLacZ
Gene: Vsx1  Location: Chr2:150522622-150531057 bp, - strand  Genetic Position: Chr2, 74.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:88182
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 86 bp of the exon 1 coding region were replaced when cassettes encoding lacZ and neo were inserted at the start codon. The remaining sequence of exon 1 and downstream exons were left intact. No protein was detected in homozygous mutant retinal tissue by immunofluorescence. lacZ expression was visualized via beta-gal staining. (J:88182)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vsx1 Mutation:  9 strains or lines available
Original:  J:88182 Chow RL, et al., Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1754-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory