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Targeted Allele Detail
Symbol: Qktm1Imeg
Name: quaking; targeted mutation 1, Institute of Molecular Embryology and Genetics
MGI ID: MGI:3033861
Synonyms: qkI-
Gene: Qk  Location: Chr17:10206471-10319361 bp, - strand  Genetic Position: Chr17, 7.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:88215
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of intron 1 and the first part of the coding sequence in exon 2, which includes the initiation sequence and the codons for the first 44 amino acids, were replaced with an IRES and a betageo fusion gene. This removes the highly conserved QUA1 domain in the encoded protein. Absence of transcription of the endogenous gene was demonstrated by RT-PCR. Beta-galactosidase is expressed from this allele. (J:88215)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Qk Mutation:  4 strains or lines available
Original:  J:88215 Li Z, et al., Defective smooth muscle development in qkI-deficient mice. Dev Growth Differ. 2003 Oct-Dec;45(5-6):449-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory