Pfibs1^BALB/c
QTL Variant Detail

Summary

• QTL variant: Pfibs1^BALB/c
• Name: pulmonary fibrosis susceptibility 1; BALB/c
• MGI ID: MGI:3033794
• QTL: Pfibs1 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: BALB/c

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:75407

Inbred mouse strain (DBA/2) is highly susceptible to bleomycin-induced pulmonary fibrosis and is genetically very dissimilar to the standard fibrosis-sensitive strain, C57BL/6. The strain difference enabled the authors to genetically map the loci underlying the phenotype. One marker named Pfibs1, mapped within a region of mouse Chromosome 6 that contains a cluster of genes that are members of the tumor necrosis factor (TNF)-receptor family. A second locus, Pfibs2 mapped within a region of mouse Chromosome 13 that included the Fgf gene family.

References

• Original: J:75407 Barth RK, et al., Mapping susceptibility genes for the induction of pulmonary fibrosis in mice. Chest. 2002 Mar;121(3 Suppl):21S
• All: 1 reference(s)