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Cd276tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Cd276tm1Mak
Name: CD276 antigen; targeted mutation 1, Tak Mak
MGI ID: MGI:3033707
Synonyms: B7-H3-
Gene: Cd276  Location: Chr9:58524300-58555033 bp, - strand  Genetic Position: Chr9, 31.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84973
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsHomologous recombination was used to replace a 3.2 kb genomic fragment including the exon encoding the second immunoglobulin domain with a neomycin cassette in antisense orientation relative to transcription. RT-PCR and flow cytometric analysis indicated an absence of transcript and protein, respectively, in homozygous mutant MEFs. (J:84973)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd276 Mutation:  6 strains or lines available
References
Original:  J:84973 Suh WK, et al., The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol. 2003 Sep;4(9):899-906
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory