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Targeted Allele Detail
Symbol: Dph1tm1Bhr
Name: diphthamide biosynthesis 1; targeted mutation 1, Richard R Behringer
MGI ID: MGI:3033421
Synonyms: Ovca1 -
Gene: Dph1  Location: Chr11:75177643-75191241 bp, - strand  Genetic Position: Chr11, 45.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:88090
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA linker containing stop codons in all three reading frames together with a floxed neomycin resistance cassette were introduced into exon 3. Targeting took place in ES cells homozygous for the Tg(Prm-cre)70Og transgene. Cre-mediated excision subsequently removed the neomycin cassette upon transmission from male chimeric mice. mRNA transcripts were produced but Western blot analysis demonstrated the absence of protein. (J:88090)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dph1 Mutation:  19 strains or lines available
Original:  J:88090 Chen CM, et al., Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis. Genes Dev. 2004 Feb 1;18(3):320-32
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory