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Chemically induced Allele Detail
Symbol: GckRgsc475
Name: glucokinase; RIKEN Genomic Sciences Center (GSC), 475
MGI ID: MGI:3033226
Synonyms: early onset diabetes, 5 RIKEN GSC, Gck5Rgsc, GckY273Stop, M-475, Rgsc475
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Strain of Origin:  C57BL/6J
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsC to A transversion in exon 7 results in a nonsense mutation and changes a Tyrosine into a stop at amino acid 273. Real time PCR and immunoblotting found decreased liver Gck mRNA, protein expression and Gck activity were reduced. (J:88919, J:137483)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  26 strains or lines available
Original:  J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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