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Chemically induced Allele Detail
Symbol: GckRgsc392
Name: glucokinase; RIKEN Genomic Sciences Center (GSC), 392
MGI ID: MGI:3033225
Synonyms: early onset diabetes, 4 RIKEN GSC, Gck4Rgsc, GckV182M, M-392, Rgsc392
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Strain of Origin:  C57BL/6J
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsG to A transition in exon 5 results in a missense mutation and substitution of methionine for valine at amino acid 182. Real time PCR and immunoblotting found no change in liver Gck mRNA and protein expression however liver Gck activity was reduced. This same mutation is found in human MODY2 patients (J:88919, J:137483)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  24 strains or lines available
Original:  J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory