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Chemically induced Allele Detail
Symbol: GckRgsc341
Name: glucokinase; RIKEN Genomic Sciences Center (GSC), 341
MGI ID: MGI:3033224
Synonyms: early onset diabetes, 3 RIKEN GSC, Gck3Rgsc, GckC220Y, M-341, Rgsc341
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Strain of Origin:  C57BL/6J
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsG to A transition in exon 6 results in a missense mutation and substitution of tyrosine for cysteine at amino acid 220. Real time PCR detected no change in Gck mRNA expression however protein levels and Gck activity are reduced. (J:88919, J:137483)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  26 strains or lines available
Original:  J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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