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Chemically induced Allele Detail
Symbol: GckRgsc272
Name: glucokinase; early onset diabetes, 2 RIKEN GSC
MGI ID: MGI:3033223
Synonyms: early onset diabetes, 2 RIKEN GSC, Gck2Rgsc, GckM224R, M-272, Rgsc272
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsT to G transversion in exon 6 results in a missense mutation and substitution of arginine for methionine at amino acid 224. Real time PCR on liver samples detected no change in Gck mRNA expression however liver protein levels and Gck activity are reduced (J:88919, J:137483)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  26 strains or lines available
Original:  J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory