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Chemically induced Allele Detail
Symbol: GckRgsc210
Name: glucokinase; RIKEN Genomic Sciences Center (GSC), 210
MGI ID: MGI:3033222
Synonyms: early onset diabetes, 2 RIKEN GSC, Gck1Rgsc, GckIVS1A+1G-T, M-210, Rgsc210
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Strain of Origin:  C57BL/6J
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsG to T transversion in the first exon at a beta cell specific splice donor site (IVS1A+1) was found. No change in liver Gck mRNA expression, protein expression, or activity was detected. This same mutation is found in human MODY2 patients. (J:88919, J:137483)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  26 strains or lines available
Original:  J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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