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Chemically induced Allele Detail
Symbol: GckRgsc210
Name: glucokinase; RIKEN Genomic Sciences Center (GSC), 210
MGI ID: MGI:3033222
Synonyms: early onset diabetes, 2 RIKEN GSC, Gck1Rgsc, GckIVS1A+1G-T, M-210, Rgsc210
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Strain of Origin:  C57BL/6J
Project Collection: RIKEN GSC ENU Project
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsG to T transversion in the first exon at a beta cell specific splice donor site (IVS1A+1) was found. No change in liver Gck mRNA expression, protein expression, or activity was detected. This same mutation is found in human MODY2 patients. (J:88919, J:137483)
Inheritance:    Dominant
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  37 strains or lines available
Original:  J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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