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Grxcr1pi-3J
Spontaneous Allele Detail
Nomenclature
Symbol: Grxcr1pi-3J
Name: glutaredoxin, cysteine rich 1; pirouette 3 Jackson
MGI ID: MGI:3029627
Gene: Grxcr1  Location: Chr5:68189178-68323741 bp, + strand  Genetic Position: Chr5, 36.59 cM
Mutation
origin
Strain of Origin:  BKS.Cg-Dock7m +/+ Leprdb/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsGenomic PCR demonstrated a deletion with a maximum size of approximately 200 kb that includes exon 1, nearly 125 kb of upstream sequence, and the majority of intron 1. The deletion breakpoint in intron 1 is within 12 kb of exon 2. (J:156811)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grxcr1 Mutation:  19 strains or lines available
References
Original:  J:156811 Odeh H, et al., Mutations in Grxcr1 are the basis for inner ear dysfunction in the pirouette mouse. Am J Hum Genet. 2010 Feb 12;86(2):148-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory