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Slc8a3tm1Sso
Targeted Allele Detail
Nomenclature
Symbol: Slc8a3tm1Sso
Name: solute carrier family 8 (sodium/calcium exchanger), member 3; targeted mutation 1, Sophie Sokolow
MGI ID: MGI:3028976
Synonyms: Ncx3-/-
Gene: Slc8a3  Location: Chr12:81197915-81333180 bp, - strand  Genetic Position: Chr12, 37.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87615
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted in exon 2. Absence of mRNA was confirmed by hybridization assay and by RT-PCR. Absence of protein was demonstrated immunologically and by Western blot analysis. (J:87615)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc8a3 Mutation:  34 strains or lines available
References
Original:  J:87615 Sokolow S, et al., Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. J Clin Invest. 2004 Jan;113(2):265-73
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory