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Ripk3tm1Vmd
Targeted Allele Detail
Nomenclature
Symbol: Ripk3tm1Vmd
Name: receptor-interacting serine-threonine kinase 3; targeted mutation 1, Vishva M Dixit
MGI ID: MGI:3028853
Synonyms: rip3-
Gene: Ripk3  Location: Chr14:55784995-55788857 bp, - strand  Genetic Position: Chr14, 28.19 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87683
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA sequence fragment encompassing exons 1 through 3 was replaced with a floxed PGK-neo cassette. Protein was undetected by Western blot analysis of homozygous mutant MEFs, bone marrow-derived macrophages, B and T lymphocytes, and thymocytes. (J:87683)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ripk3 Mutation:  22 strains or lines available
References
Original:  J:87683 Newton K, et al., Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol. 2004 Feb;24(4):1464-9
All:  150 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory