Del(17Hspa1b-Hsp1a)1Dix
Targeted Allele Detail

Summary

• Symbol: Del(17Hspa1b-Hsp1a)1Dix
• Name: deletion, Chr 17, David J Dix 1
• MGI ID: MGI:3028843
• Synonyms: Hsp70.1/3^-, Hspa1a/Hspa1b^tm1Dix, Hspa1a/Hspa1b^tm1Tkp, Hspa1a^tm1Hamp
• Gene: Del(17Hspa1b-Hsp1a)1Dix Location: unknown Genetic Position: Chr17, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87581
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(17Hspa1b-Hsp1a)1Dix involves 4 genes/genome features (Hspa1b, 7330403C04Rik, Hspa1a ...) View all
• Mutation details: Portions of both Hspa1a and Hspa1b were replaced with a single neomycin selection cassette inserted by homologous recombination. Neither Hspa1a nor Hspa1b transcript was detected by Northern blot analysis of homozygous mutant MEFs (before and after heat shock). Western blot analysis confirmed the absence of both protein species in homozygous mutant MEFs after heat shock treatment. (J:87581)

Tumor Data

List all tumor models in MMHCdb carrying Del(17Hspa1b-Hsp1a)1Dix

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Del(17Hspa1b-Hsp1a)1Dix Mutation: 3 strains or lines available

References

• Original: J:87581 Hunt CR, et al., Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice. Mol Cell Biol. 2004 Jan;24(2):899-911
• All: 42 reference(s)