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Targeted Allele Detail
Symbol: Mmp24tm1Ski
Name: matrix metallopeptidase 24; targeted mutation 1, Motoharu Seiki
MGI ID: MGI:3028827
Gene: Mmp24  Location: Chr2:155775342-155818366 bp, + strand  Genetic Position: Chr2, 77.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:87586
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 5 and part of exon 6 were replaced with a MCI-neomycin cassette. This resulted in the loss of the zinc binding site in the catalytic domain and a frame shift at the exon 4-exon 7 junction. Northern blot analysis indicated a faint band representing the mutant transcript which codes only the propeptide and N-terminal part of the catalytic fragment. (J:87586)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp24 Mutation:  2 strains or lines available
Original:  J:87586 Komori K, et al., Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase. FEBS Lett. 2004 Jan 16;557(1-3):125-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory