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Pik3r1tm1Khn
Targeted Allele Detail
Nomenclature
Symbol: Pik3r1tm1Khn
Name: phosphoinositide-3-kinase regulatory subunit 1; targeted mutation 1, C Ronald Kahn
MGI ID: MGI:3028729
Synonyms: p55alpha-/p50alpha-
Gene: Pik3r1  Location: Chr13:101680563-101768217 bp, - strand  Genetic Position: Chr13, 53.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87598
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1B and 1C were replaced by an inverted neomycin cassette. Western blot analysis confirmed the absence of p50alpha and p55alpha products without affecting p85alpha product (J:87598)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3r1 Mutation:  42 strains or lines available
References
Original:  J:87598 Chen D, et al., p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol. 2004 Jan;24(1):320-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory