About   Help   FAQ
Pik3r1tm1Khn
Targeted Allele Detail
Summary
Symbol: Pik3r1tm1Khn
Name: phosphoinositide-3-kinase regulatory subunit 1; targeted mutation 1, C Ronald Kahn
MGI ID: MGI:3028729
Synonyms: p55alpha-/p50alpha-
Gene: Pik3r1  Location: Chr13:101817269-101904725 bp, - strand  Genetic Position: Chr13, 53.92 cM
Alliance: Pik3r1tm1Khn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87598
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1B and 1C were replaced by an inverted neomycin cassette. Western blot analysis confirmed the absence of p50alpha and p55alpha products without affecting p85alpha product (J:87598)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3r1 Mutation:  55 strains or lines available
References
Original:  J:87598 Chen D, et al., p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol. 2004 Jan;24(1):320-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory