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QTL Variant Detail
QTL variant: Bbaa20C57BL/6N
Name: B.burgdorferi-associated arthritis 20; C57BL/6N
MGI ID: MGI:3028677
QTL: Bbaa20  Location: Chr6:71322621-93464093 bp  Genetic Position: Chr6, Syntenic
Strain of Specimen:  C57BL/6N
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa20, was identified in the (C3H/HeJ X BALB/cAnN)F1 X BALB/cAnN backcross on Chr 6. Bbaa20 was linked to IgG levels after infection with B.burgdorferi. It mapped from 30.5 - 38.5 cM between markers D6Mit16 and D6Mit102, LRT=18.9 accounting for 14.8% variance.

The reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross also confirmed the previously identified Bbaa5 QTL on Chr 6. Using CIM Bbaa5 linked to specific IgM, at 71.6 cM with marker D6Mit200, LRT=24.4 and total IgM from 43.0 -67.0 cM between marker D6Mit230 and D6Mit59, LRT=29.2. [Table 3.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

Original:  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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