About   Help   FAQ
Bbaa16C57BL/6N
QTL Variant Detail
Nomenclature
QTL variant: Bbaa16C57BL/6N
Name: B.burgdorferi-associated arthritis 16; C57BL/6N
MGI ID: MGI:3028671
QTL: Bbaa16  Location: Chr7:36580590-116817642 bp  Genetic Position: Chr7, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6N
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73060

Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa16, was identified in the (C57BL/6N X C3H/HeN)F1 X C3H/HeN backcross on Chr 7. Bbaa16 was linked to total IgG levels after infection with B.burgdorferi. It mapped from 16.0 - 53.0 cM between markers D7Mit227 and D7Mit40, LRT=20.1 accounting for 6.8% variance. [Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

References
Original:  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/05/2019
MGI 6.14
The Jackson Laboratory