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QTL Variant Detail
QTL variant: Bbaa16C57BL/6N
Name: B.burgdorferi-associated arthritis 16; C57BL/6N
MGI ID: MGI:3028671
QTL: Bbaa16  Location: Chr7:36580590-116817642 bp  Genetic Position: Chr7, Syntenic
Strain of Specimen:  C57BL/6N
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.

A novel QTL, Bbaa16, was identified in the (C57BL/6N X C3H/HeN)F1 X C3H/HeN backcross on Chr 7. Bbaa16 was linked to total IgG levels after infection with B.burgdorferi. It mapped from 16.0 - 53.0 cM between markers D7Mit227 and D7Mit40, LRT=20.1 accounting for 6.8% variance. [Table 2.]

C3H/HeN-derived alleles are associated with increased arthritis susceptibility and severity at all QTL mapped in this experiment.

Original:  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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