About   Help   FAQ
Targeted Allele Detail
Symbol: Ercc4tm1Fwa
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4; targeted mutation 1, Frederick W Alt
MGI ID: MGI:3028660
Synonyms: XPFm
Gene: Ercc4  Location: Chr16:13109684-13150617 bp, + strand  Genetic Position: Chr16, 8.93 cM
Germline Transmission:  Earliest citation of germline transmission: J:87684
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsThe endogenous exon 8 was replaced with a mutant version containing a nonsense mutation at codon 445. A single loxP site remained in intron 7 after the excision of a floxed neo cassette. Though the mutation was expected to generate a truncated transcript, message was undetected by RT-PCR analysis of homozygous mutant MEFs. (J:87684)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc4 Mutation:  74 strains or lines available
Original:  J:87684 Tian M, et al., Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol Cell Biol. 2004 Feb;24(3):1200-5
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory