C5ar1^tm1Raw
Targeted Allele Detail

Summary

• Symbol: C5ar1^tm1Raw
• Name: complement component 5a receptor 1; targeted mutation 1, Rick A Wetsel
• MGI ID: MGI:3028524
• Synonyms: C5aR^-, CD88^-
• Gene: C5ar1 Location: Chr7:15980668-15993465 bp, - strand Genetic Position: Chr7, 8.77 cM
• Alliance: C5ar1^tm1Raw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86845
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette with a 3' lox site was inserted into exon 2 and an additional loxP site was inserted upstream of exon 2. Northern blot and immunohistochemistry analyses confirm the absence of gene transcription and protein product. (J:86845, J:131606)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C5ar1 Mutation: 27 strains or lines available

References

• Original: J:86845 Girardi G, et al., Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest. 2003 Dec;112(11):1644-54
• All: 20 reference(s)