Ptprc^tm1Weis
Targeted Allele Detail

Summary

• Symbol: Ptprc^tm1Weis
• Name: protein tyrosine phosphatase receptor type C; targeted mutation 1, Arthur Weiss
• MGI ID: MGI:3027340
• Synonyms: CD45 E613R, Cd45^w, Wedge
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^tm1Weis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66501
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: To recapitulate a mutation in the orthologous human gene that disrupts the inhibitory wedge, a glutamate to arginine substitution at codon 613 (E613R) was engineered in exon 18 and incorporated at the endogenous locus via homolgous recombination. A single loxP site remained in intron 18 after the floxed neo cassette was excised. (J:66501)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 188 strains or lines available

References

• Original: J:66501 Majeti R, et al., An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 2000 Dec 22;103(7):1059-70
• All: 8 reference(s)