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Targeted Allele Detail
Symbol: Ptprctm1Weis
Name: protein tyrosine phosphatase, receptor type, C; targeted mutation 1, Arthur Weiss
MGI ID: MGI:3027340
Synonyms: CD45 E613R, Cd45w, Wedge
Gene: Ptprc  Location: Chr1:137990599-138103446 bp, - strand  Genetic Position: Chr1, 60.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:66501
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
Mutation detailsTo recapitulate a mutation in the orthologous human gene that disrupts the inhibitory wedge, a glutamate to arginine substitution at codon 613 (E613R) was engineered in exon 18 and incorporated at the endogenous locus via homolgous recombination. A single loxP site remained in intron 18 after the floxed neo cassette was excised. (J:66501)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:  142 strains or lines available
Original:  J:66501 Majeti R, et al., An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 2000 Dec 22;103(7):1059-70
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory