Tg(mI56i-cre)6-2Clou
Transgene Detail

Summary

• Symbol: Tg(mI56i-cre)6-2Clou
• Name: transgene insertion 6-2, David E Clouthier
• MGI ID: MGI:3027086
• Synonyms: Dlx5/6-Cre
• Transgene: Tg(mI56i-cre)6-2Clou Location: unknown
• Alliance: Tg(mI56i-cre)6-2Clou page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(mI56i-cre)6-2Clou expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	mI56i (MGI:3833434)

• Mutation details: The intergenic distal-less homeobox 5/6 enhancer (mI56i) is a 440 bp fragment, endogenously located between Dlx5 and Dlx6. In this transgenic construct, mI56i was included immediately downstream of cDNA encoding a nuclear localization signal and cre. Additionally, a minimal beta-globin promoter was included in the construct. Expression of cre recombinase was first realized at E9.5 and observed in the apical ectodermal ridge, brain, and neural crest-derived mesenchyme of pharyngeal. (J:87355)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	mI56i (mouse) Summary of all recombinase alleles driven by mI56i. Comparative matrix view of recombinase activities Alliance mouse mI56i gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder lines 6-1 and 6-2 were generated. In general, the expression from line 6-1 was stronger than that of line 6-2 in all areas other than the brain.

References

• Original: J:87355 Ruest LB, et al., Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain. Genesis. 2003 Dec;37(4):188-94
• All: 1 reference(s)