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Spon2tm1Mjb
Targeted Allele Detail
Nomenclature
Symbol: Spon2tm1Mjb
Name: spondin 2, extracellular matrix protein; targeted mutation 1, Michael J Bevan
MGI ID: MGI:3026870
Synonyms: Mindin -/-
Gene: Spon2  Location: Chr5:33198184-33218455 bp, - strand  Genetic Position: Chr5, 17.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87393
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 1 and all of exons 2 and 3 were replaced with a neomycin resistance gene. Absence of of mRNA was confirmed by RT-PCR and protein was undetectable in lymphnodes by immunoblot analysis. (J:87393)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spon2 Mutation:  9 strains or lines available
References
Original:  J:87393 He YW, et al., The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol. 2004 Jan;5(1):88-97
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory