About   Help   FAQ
Targeted Allele Detail
Symbol: Epha4tm5Kln
Name: Eph receptor A4; targeted mutation 5, Rudiger Klein
MGI ID: MGI:3026688
Synonyms: Epha4EGFP, Epha4gf
Gene: Epha4  Location: Chr1:77367185-77515088 bp, - strand  Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
Germline Transmission:  Earliest citation of germline transmission: J:87398
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe endogenous locus was disrupted by the insertion of sequence encoding EGFP in frame in exon 3. A truncated protein, in which the cytoplasmic domain was putatively replaced with GFP and thus lacked all intracellular binding sites, was identified in mutant mice by Western blot analysis of hippocampal lysates. (J:87398)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epha4 Mutation:  9 strains or lines available
Original:  J:87398 Grunwald IC, et al., Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci. 2004 Jan;7(1):33-40
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory