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Epha4tm5Kln
Targeted Allele Detail
Nomenclature
Symbol: Epha4tm5Kln
Name: Eph receptor A4; targeted mutation 5, Rudiger Klein
MGI ID: MGI:3026688
Synonyms: Epha4EGFP, Epha4gf
Gene: Epha4  Location: Chr1:77367185-77515088 bp, - strand  Genetic Position: Chr1, 39.55 cM, cytoband C1-C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87398
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of sequence encoding EGFP in frame in exon 3. A truncated protein, in which the cytoplasmic domain was putatively replaced with GFP and thus lacked all intracellular binding sites, was identified in mutant mice by Western blot analysis of hippocampal lysates. (J:87398)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epha4 Mutation:  9 strains or lines available
References
Original:  J:87398 Grunwald IC, et al., Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci. 2004 Jan;7(1):33-40
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory