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TxnipHyplip1
Spontaneous Allele Detail
Nomenclature
Symbol: TxnipHyplip1
Name: thioredoxin interacting protein; hyperlipidemia 1
MGI ID: MGI:2687368
Synonyms: Txnip-, txniphcb
Gene: Txnip  Location: Chr3:96557957-96561857 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Mutation
origin
Strain of Origin:  HcB19/Dem
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA T-to-A transversion mutation at position 337 in the 1,456-bp cDNA results in a tyrosine (TAT) to a stop codon (TAA) alteration at amino acid 97 in the encoded protein. This mutation was absent in the C3H parental strain and all other strains observed. A decreased level of mutant transcript was expressed from this allele. (J:75395)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txnip Mutation:  7 strains or lines available
References
Original:  J:47109 Castellani LW, et al., Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet. 1998 Apr;18(4):374-7
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory