Pomc^tm2Ute
Targeted Allele Detail

Summary

• Symbol: Pomc^tm2Ute
• Name: pro-opiomelanocortin-alpha; targeted mutation 2, Ute Hochgeschwender
• MGI ID: MGI:2687084
• Gene: Pomc Location: Chr12:4004951-4010642 bp, + strand Genetic Position: Chr12, 1.99 cM
• Alliance: Pomc^tm2Ute page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57503
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded all but the first 44 residues of the preprotein (all but 18 residues of the mature protein). (J:57503)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pomc Mutation: 19 strains or lines available

References

• Original: J:57503 Yaswen L, et al., Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin [see comments]. Nat Med. 1999 Sep;5(9):1066-70
• All: 10 reference(s)