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Lpar1tm1Mcox
Targeted Allele Detail
Nomenclature
Symbol: Lpar1tm1Mcox
Name: lysophosphatidic acid receptor 1; targeted mutation 1, Peter R Maycox
MGI ID: MGI:2687056
Synonyms: lpa1(-)
Gene: Lpar1  Location: Chr4:58435255-58553898 bp, - strand  Genetic Position: Chr4, 32.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87198
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe majority of exon 3 was replaced with a cassette containing IRES-lacZ and PGK-neo. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of various tissues. (J:87198)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lpar1 Mutation:  48 strains or lines available
References
Original:  J:87198 Harrison SM, et al., LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Mol Cell Neurosci. 2003 Dec;24(4):1170-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory