Lpar1^tm1Mcox
Targeted Allele Detail

Summary

• Symbol: Lpar1^tm1Mcox
• Name: lysophosphatidic acid receptor 1; targeted mutation 1, Peter R Maycox
• MGI ID: MGI:2687056
• Synonyms: lpa1^(-)
• Gene: Lpar1 Location: Chr4:58435255-58553898 bp, - strand Genetic Position: Chr4, 32.2 cM
• Alliance: Lpar1^tm1Mcox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87198
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of exon 3 was replaced with a cassette containing IRES-lacZ and PGK-neo. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of various tissues. (J:87198)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpar1 Mutation: 70 strains or lines available

References

• Original: J:87198 Harrison SM, et al., LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Mol Cell Neurosci. 2003 Dec;24(4):1170-9
• All: 3 reference(s)