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Hcn1tm2Kndl
Targeted Allele Detail
Nomenclature
Symbol: Hcn1tm2Kndl
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1; targeted mutation 2, Eric R Kandel
MGI ID: MGI:2686951
Synonyms: Hcn1-, HCN1 knockout
Gene: Hcn1  Location: Chr13:117602320-117981028 bp, + strand  Genetic Position: Chr13, 66.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86763
Parent Cell Line:  MM13 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of the pore-S6 domain containing exon. At the same time, a floxed neomycin cassette was introduced downstream. Cells in which transient Cre recombinase expression of properly targeted ES cells resulted in excision of both the neomycin gene and the pore-S6 exon were selected. Both mRNA and protein were shown to be absent in the brains of mice homozygous for this allele. (J:86763)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Hcn1 Mutation:  30 strains or lines available
References
Original:  J:86763 Nolan MF, et al., The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell. 2003 Nov 26;115(5):551-64
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory