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Targeted Allele Detail
Symbol: Mpltm1Fjs
Name: myeloproliferative leukemia virus oncogene; targeted mutation 1, Frederic J de Sauvage
MGI ID: MGI:2686901
Synonyms: c-Mpl-, c-Mpl delta60
Gene: Mpl  Location: Chr4:118442415-118457513 bp, - strand  Genetic Position: Chr4, 54.61 cM, cytoband D
Germline Transmission:  Earliest citation of germline transmission: J:87416
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 11 and 12, which includes the sequence for the intracellular region, were replaced with a complex sequence including a cDNA fragment encoding only the first half of the cytoplasmic signaling domain, an SV40 polyadenylation site, and a floxed PGK-neomycin cassette. Western blot analysis demonstrated that the resulting protein product had been modified to a size consistent with a 60 amino acid deletion. (J:87416)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mpl Mutation:  2 strains or lines available
Original:  J:87416 Luoh SM, et al., Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo. Mol Cell Biol. 2000 Jan;20(2):507-15
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory