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Del(11Jmjd6-Mettl23)1Flv
Targeted Allele Detail
Summary
Symbol: Del(11Jmjd6-Mettl23)1Flv
Name: deletion, Chr 11, Richard A Flavell 1
MGI ID: MGI:2686850
Synonyms: Jmjd6tm1Flv, PSR -
Gene: Del(11Jmjd6-Mettl23)1Flv  Location: unknown  Genetic Position: Chr11, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86771
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(11Jmjd6-Mettl23)1Flv involves 2 genes/genome features (Jmjd6, Mettl23) View all
 
Mutation detailsThe first 2 exons were replaced with a neomycin resistance gene. Absence of expression after this gene modification was confirmed by Northern blot analysis. A subsequent publication demonstrated that the targeting vector also replaced the first exon of the neighboring gene Mettl23, located on the opposite strand. RT-PCR confirmed absence of Mettl23 mRNA in homozygous embryos. (J:86771, J:137989)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(11Jmjd6-Mettl23)1Flv Mutation:  0 strains or lines available
References
Original:  J:86771 Li MO, et al., Phosphatidylserine receptor is required for clearance of apoptotic cells. Science. 2003 Nov 28;302(5650):1560-3
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory