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Tg(Rho)1Wbae
Transgene Detail
Nomenclature
Symbol: Tg(Rho)1Wbae
Name: transgene insertion 1, Wolfgang Baehr
MGI ID: MGI:2686794
Synonyms: VPP
Transgene: Tg(Rho)1Wbae  Location: unknown  
Temporal progressive retinal changes in normal and Tg(Rho)1Wbae/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Rho)1Wbae expresses 1 gene
 
Mutation detailsThe transgenic construct contained a 15 kb genomic fragment encompassing the mouse rhodopsin gene. 3 substitution mutations were engineered in exon 1 (V20G, P23H, and P27L). 6 kb of upstream sequence and 3 kb of downstream sequence were included in the construct. Northern blot analysis showed that both the inserted mutant rhodopsin transcript and the wild-type transcript are present in transgenic mice, indicating that the site of integration is not at the endogenous rhodopsin locus. (J:12791)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:12791 Naash MI, et al., Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5499-503
All:  14 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory