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Targeted Allele Detail
Symbol: Nocttm1Bjc
Name: nocturnin; targeted mutation 1, JC Besharse
MGI ID: MGI:2686733
Synonyms: Noc-
Gene: Noct  Location: Chr3:51224447-51251644 bp, + strand  Genetic Position: Chr3, 22.12 cM, cytoband B-D
Nocttm1Bjc/Nocttm1Bjc mice exhibit a diet-dependent lean phenotype

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:122301
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of exon 3, which contains most of the protein coding sequence including the catalytic domain, was replaced with a neomycin resistance cassette. Absence of protein was confirmed in mutant liver homogenates. (J:122301)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Noct Mutation:  38 strains or lines available
Original:  J:122301 Green CB, et al., Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9888-93
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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