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Targeted Allele Detail
Symbol: Malt1tm1Vmd
Name: MALT1 paracaspase; targeted mutation 1, Vishva M Dixit
MGI ID: MGI:2684761
Synonyms: paracaspase-
Gene: Malt1  Location: Chr18:65430939-65478888 bp, + strand  Genetic Position: Chr18, 38.56 cM
Germline Transmission:  Earliest citation of germline transmission: J:86770
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed neomycin resistance gene was placed in intron 10 and an additional loxP site was placed in intron 12. Transient transfection of correctly targeted ES cells with a plasmid expressing Cre-recombinase eliminated the neomycin gene along with exons 11 and 12. Absence of protein product in resulting homozygous mice was demonstrated by Western blot analysis. (J:86770)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Malt1 Mutation:  13 strains or lines available
Original:  J:86770 Ruefli-Brasse AA, et al., Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science. 2003 Nov 28;302(5650):1581-4
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory