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Emx1tm1(cre)Krj
Targeted Allele Detail
Summary
Symbol: Emx1tm1(cre)Krj
Name: empty spiracles homeobox 1; targeted mutation 1, Kevin R Jones
MGI ID: MGI:2684610
Synonyms: emx1-cre, Emx1Cre, Emx1-Cre, Emx1IREScre, Emx1-IRES-Cre
Gene: Emx1  Location: Chr6:85164913-85181445 bp, + strand  Genetic Position: Chr6, 37.21 cM
Alliance: Emx1tm1(cre)Krj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78098
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Emx1tm1(cre)Krj expression driven by 1 gene
 
Mutation detailsAn IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain. (J:78098)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Emx1 (mouse)
Summary of all recombinase alleles driven by Emx1.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:  34 strains or lines available
References
Original:  J:78098 Gorski JA, et al., Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci. 2002 Aug 1;22(15):6309-14
All:  635 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory