Twist1^Pas
Chemically induced Allele Detail

Summary

• Symbol: Twist1^Pas
• Name: twist basic helix-loop-helix transcription factor 1; Pasteur
• MGI ID: MGI:2684436
• Synonyms: Pdt
• Gene: Twist1 Location: Chr12:34007670-34009828 bp, + strand Genetic Position: Chr12, 14.81 cM, cytoband B-C1
• Alliance: Twist1^Pas page

Polydactyly in the right hindlimb of Twist1^Pas/Twist1⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BTBR

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: This ENU induced mutation was found to be alleleic through complementation analysis with a known allele at the Twist1 locus. No sequence alteration was found in the coding region of the gene. A decrease in transcript was noted by in situ hybridization. (J:86815)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Twist1 Mutation: 18 strains or lines available

References

• Original: J:8293 Shedlovsky A, et al., Induction of recessive lethal mutations in the T/t-H-2 region of the mouse genome by a point mutagen. Genet Res. 1986 Apr;47(2):135-42
• All: 2 reference(s)