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Targeted Allele Detail
Symbol: Kltm1Yin
Name: klotho; targeted mutation 1, Yo-ichi Nabeshima
MGI ID: MGI:2684400
Synonyms: kl-
Gene: Kl  Location: Chr5:150952607-150993809 bp, + strand  Genetic Position: Chr5, 89.77 cM, cytoband G3
Germline Transmission:  Earliest citation of germline transmission: J:86859
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 1 was disrupted by homologous recombination of a targeting vector. Protein was undetected in homozygous mutant mice. (J:86859)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kl Mutation:  5 strains or lines available
Original:  J:86859 Tsujikawa H, et al., Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol. 2003 Dec;17(12):2393-403
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory