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Tg(Neurog3-cre/Esr1*)1Dam
Transgene Detail
Nomenclature
Symbol: Tg(Neurog3-cre/Esr1*)1Dam
Name: transgene insertion 1, Douglas A Melton
MGI ID: MGI:2684324
Synonyms: Ngn3-Cre, Ngn3/CreERTM, Tg(Neurog3-cre/Esr1)1Dam
Transgene: Tg(Neurog3-cre/Esr1*)1Dam  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsSequence encoding a tamoxifen inducible form of a cre recombinase/estrogen receptor fusion protein was adjoined to a 6.7 kb Neurog3 promoter fragment. The neurogenin 3 promoter drives expression of cre recombinase in the islet cells of the pancreas. (J:76095)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neurog3     Summary of all recombinase alleles driven by Neurog3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:76095 Gu G, et al., Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May;129(10):2447-57
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory