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Gt(ROSA)26Sortm1(Notch1)Dam
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Notch1)Dam
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas A Melton
MGI ID: MGI:2684314
Synonyms: Lox-stop-Lox-RosaNICD-ires-GFP, R26fN1-ICD, R26N1ICD, R26-NICD, R26NotchIC, R-NICD, Rosa26LSL-NICD, Rosa26N1ICD, Rosa26NIC, Rosa26NotchIC-IRES-GFP, Rosa26-StopFloxed-NICD, RosaICNLSL, RosaN1-IC, RosaNICD, ROSA-NICD, RosaNICD1, RosaNICDflox, RosaNotch, Rosa-NotchIC-IRES-GFP, TGNICDflox
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86975
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Notch1)Dam expresses 1 gene
 
Mutation detailsA targeting vector containing a floxed neo cassette followed by a mouse Notch1 sequence fragment and GFP was inserted at the endogenous locus. Excision of the floxed neo cassette leads to the expression of the Notch1 sequence encoding an intracellular portion of NOTCH1 (amino acids 1749-2293), but lacking the c-terminal PEST domain. IRES preceded the sequence encoding the nuclear-localized enhanced GFP. (J:86975)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  572 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Liposarcoma, Dedifferentiated J:237232 in double Gt(ROSA)26Sortm1(Notch1)Dam and Tg(Adipoq-cre)1Evdr mutants.

Phenotypic Similarity to Human Syndrome: Osteosclerosis J: 233131 in double Gt(ROSA)26Sortm1(Notch1)Dam and Tg(Col1a1-cre)1Kry mutants.

References
Original:  J:86975 Murtaugh LC, et al., Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14920-5
All:  195 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory