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Targeted Allele Detail
Symbol: F13a1tm1Gdi
Name: coagulation factor XIII, A1 subunit; targeted mutation 1, Gerhard Dickneite
MGI ID: MGI:2684302
Synonyms: FXIII-, FXIII-A-
Gene: F13a1  Location: Chr13:36867178-37050244 bp, - strand  Genetic Position: Chr13, 14.44 cM
Altered response to myocardial infraction in F13a1tm1Gdi/F13a1tm1Gdi mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:87293
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.5 kb fragment encompassing exon 7 was replaced with a neomycin selection cassette inserted by homologous recombination. Both coagulation factor XIII enzymatic activity and fibrin gamma-dimerization were undetected in plasma from homozygous mutant mice. (J:87293)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F13a1 Mutation:  26 strains or lines available
Original:  J:87293 Lauer P, et al., Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit. Thromb Haemost. 2002 Dec;88(6):967-74
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory