About   Help   FAQ
Mcl1tm2Sjk
Targeted Allele Detail
Nomenclature
Symbol: Mcl1tm2Sjk
Name: myeloid cell leukemia sequence 1; targeted mutation 2, Stanley J Korsmeyer
MGI ID: MGI:2684150
Synonyms: Mcl1-bGeo, Mcl-1null
Gene: Mcl1  Location: Chr3:95658788-95663176 bp, + strand  Genetic Position: Chr3, 40.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86906
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA sequence fragment extending from within exon 1 through a 5' portion of exon 2 was replaced with an IRES-betageo cassette. Western blot analysis of mutant murine embryonic fibroblasts indicated that no normal protein is produced from this allele. (J:86906)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mcl1 Mutation:  30 strains or lines available
References
Original:  J:86906 Opferman JT, et al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003 Dec 11;426(6967):671-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory