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Targeted Allele Detail
Symbol: Mcl1tm2Sjk
Name: myeloid cell leukemia sequence 1; targeted mutation 2, Stanley J Korsmeyer
MGI ID: MGI:2684150
Synonyms: Mcl1-bGeo, Mcl-1null
Gene: Mcl1  Location: Chr3:95658788-95663176 bp, + strand  Genetic Position: Chr3, 40.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:86906
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA sequence fragment extending from within exon 1 through a 5' portion of exon 2 was replaced with an IRES-betageo cassette. Western blot analysis of mutant murine embryonic fibroblasts indicated that no normal protein is produced from this allele. (J:86906)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mcl1 Mutation:  30 strains or lines available
Original:  J:86906 Opferman JT, et al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003 Dec 11;426(6967):671-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory