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Gata3tm1Iho
Targeted Allele Detail
Nomenclature
Symbol: Gata3tm1Iho
Name: GATA binding protein 3; targeted mutation 1, I-Cheng Ho
MGI ID: MGI:2683927
Synonyms: FF, Gata3Ho
Gene: Gata3  Location: Chr2:9857078-9887953 bp, - strand  Genetic Position: Chr2, 6.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86996
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA genomic fragment containing the endogenous exons 4 and 5 was replaced with a loxP flanked cassette containing exons 4, 5, and 6 followed by neo. A PGK promoter and EGFP were included 5' and 3' of the floxed region, respectively, such that recombination of the loxP sites will place EGFP under control of the PGK promoter. (J:86996)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata3 Mutation:  6 strains or lines available
References
Original:  J:86996 Pai SY, et al., Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 2003 Dec;19(6):863-75
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory