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Targeted Allele Detail
Symbol: Plxnc1tm1Alk
Name: plexin C1; targeted mutation 1, Alex L Kolodkin
MGI ID: MGI:2683882
Synonyms: plexinC1-
Gene: Plxnc1  Location: Chr10:94790866-94944835 bp, - strand  Genetic Position: Chr10, 49.09 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:87191
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was inserted into exon 1 downstream of the start codon. Immunohistochemical analysis of pituitary sections indicated an absence of protein in homozygous mutant mice. The absence of functional protein produced by this allele was further supported by flow cytometric analysis of splenic cells. (J:87191)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plxnc1 Mutation:  4 strains or lines available
Original:  J:87191 Pasterkamp RJ, et al., Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory