Blmtm3Ches
Targeted Allele Detail
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Symbol: |
Blmtm3Ches |
Name: |
Bloom syndrome, RecQ like helicase; targeted mutation 3, Nicholas Chester |
MGI ID: |
MGI:2683764 |
Synonyms: |
Blm- |
Gene: |
Blm Location: Chr7:80104741-80184896 bp, - strand Genetic Position: Chr7, 45.65 cM
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Alliance: |
Blmtm3Ches page
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Germline Transmission: |
Earliest citation of germline transmission:
J:86827
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A floxed PGK-neomycin resistance gene was inserted into intron 8 and an additional loxP site was placed in intron 7, 75 bp from the start of exon 8. Both exon 8 and the neomycin gene were subsequently removed from correctly targeted ES cells by Cre-mediated recombination. A frame shift mutation is predicted at the splice site between exon 7 and exon 9 in the resulting transcript.
(J:86827)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Blm Mutation: |
87 strains or lines available
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Original: |
J:86827 McDaniel LD, et al., Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. DNA Repair (Amst). 2003 Dec 9;2(12):1387-404 |
All: |
3 reference(s) |
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