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St14tm1Bug
Targeted Allele Detail
Nomenclature
Symbol: St14tm1Bug
Name: suppression of tumorigenicity 14 (colon carcinoma); targeted mutation 1, Thomas H Bugge
MGI ID: MGI:2683707
Synonyms: Matriptase/MT-SP1
Gene: St14  Location: Chr9:31089402-31131853 bp, - strand  Genetic Position: Chr9, 16.61 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87125
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment encompassing 350 bp of the putative intron 1 and the majority of the putative exon 2 was replaced with an hprt cassette inserted by homologous recombination. The deleted region encoded 19 of the 24 residues of the signal anchor required for membrane translocation. RT-PCR analysis identified mutant transcript in which the putative exon 1 spliced to the putative exon 3. This aberrant splice event results in a frameshift and ultimately a premature stop codon. (J:87125)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any St14 Mutation:  4 strains or lines available
References
Original:  J:87125 List K, et al., Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene. 2002 May 23;21(23):3765-79
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory