Icos^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Icos^tm1Flv
• Name: inducible T cell co-stimulator; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2683635
• Synonyms: ICOS^-
• Gene: Icos Location: Chr1:61017086-61039479 bp, + strand Genetic Position: Chr1, 30.6 cM
• Alliance: Icos^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87123
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The three exons for all of the amino acid coding sequence except the leader peptide were replaced with a PGK-neomycin resistance cassette. Absence of protein product was demonstrated immunologically. (J:87123)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Icos Mutation: 35 strains or lines available

References

• Original: J:87123 Dong C, et al., ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 2001 Jan 4;409(6816):97-101
• All: 36 reference(s)