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Men1tm1.2Ctre
Targeted Allele Detail
Nomenclature
Symbol: Men1tm1.2Ctre
Name: multiple endocrine neoplasia 1; targeted mutation 1.2, Judy S Crabtree
MGI ID: MGI:2683274
Synonyms: deltaN, ΔN, dN, Men1deltaN, Men1ΔN, Men1dN
Gene: Men1  Location: Chr19:6334979-6340891 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86642
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 3 through 8 are flanked by single loxP sites in introns 2 and 8. This allele was generated by removing the floxed neo cassette from Men1tm1Ctre via cre-mediated recombination. (J:86642)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  14 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hyperparathyroidism J:86642.
References
Original:  J:86642 Libutti SK, et al., Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res. 2003 Nov 15;63(22):8022-8
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory