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Mapk1tm1Melo
Targeted Allele Detail
Nomenclature
Symbol: Mapk1tm1Melo
Name: mitogen-activated protein kinase 1; targeted mutation 1, Sylvain Meloche
MGI ID: MGI:2683190
Synonyms: Erk2-
Gene: Mapk1  Location: Chr16:16983382-17047453 bp, + strand  Genetic Position: Chr16, 10.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85868
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 3, which encodes subdomains V and VI, was disrupted by the insertion of a neomycin selection cassette. Protein was undetected in homozygous mutant embyros by Western blot analysis. (J:85868)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk1 Mutation:  24 strains or lines available
References
Original:  J:85868 Saba-El-Leil MK, et al., An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 2003 Oct;4(10):964-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory